Syvn1^tm2.1Tn
Targeted Allele Detail

Summary

• Symbol: Syvn1^tm2.1Tn
• Name: synovial apoptosis inhibitor 1, synoviolin; targeted mutation 2.1, Toshihiro Nakajima
• MGI ID: MGI:5749836
• Synonyms: Syvn1^flox
• Gene: Syvn1 Location: Chr19:6096606-6103742 bp, + strand Genetic Position: Chr19, 4.34 cM, cytoband A
• Alliance: Syvn1^tm2.1Tn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:220710
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: An FRT flanked neo cassette was inserted in intron 1 and exons 2-14 were floxed via homologous recombination. Flp mediated recombination removed the neo cassette. (J:220710)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Syvn1 Mutation: 25 strains or lines available

References

• Original: J:220710 Fujita H, et al., The E3 ligase synoviolin controls body weight and mitochondrial biogenesis through negative regulation of PGC-1beta. EMBO J. 2015 Apr 15;34(8):1042-55
• All: 2 reference(s)