Il15^Defm
Chemically induced Allele Detail

Summary

• Symbol: Il15^Defm
• Name: interleukin 15; deficient memory
• MGI ID: MGI:5749834
• Synonyms: DM, Il-15deltaE7, P191
• Gene: Il15 Location: Chr8:83058261-83129851 bp, - strand Genetic Position: Chr8, 39.33 cM
• Alliance: Il15^Defm page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU induced a C to T mutation (third position of the boxed triplet codon) in exon 7. This mutation creates a new splice site resulting in expression of an mRNA lacking a 48 bp region of the 5' end of exon 7. The mutant protein lacks the first 16 amino acids of exon 7. (J:220593)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il15 Mutation: 42 strains or lines available

References

• Original: J:220593 Lee TL, et al., An Alternatively Spliced IL-15 Isoform Modulates Abrasion-Induced Keratinocyte Activation. J Invest Dermatol. 2015 May;135(5):1329-37
• All: 1 reference(s)