Atoh7^tm2(tTA)Xmu
Targeted Allele Detail

Summary

• Symbol: Atoh7^tm2(tTA)Xmu
• Name: atonal bHLH transcription factor 7; targeted mutation 2, Xiuqian Mu
• MGI ID: MGI:5749708
• Synonyms: Atoh7^tTA
• Gene: Atoh7 Location: Chr10:62935564-62937059 bp, + strand Genetic Position: Chr10, 32.54 cM
• Alliance: Atoh7^tm2(tTA)Xmu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:220735
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Targeted (Null/knockout, Transactivator)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The open reading frame was replaced with the tetracycline-responsive artificial transcription factor tTA open reading frame and a floxed pgk-neo cassette via homologous recombination. (J:220735)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Atoh7 Mutation: 9 strains or lines available

References

• Original: J:220735 Wu F, et al., Two transcription factors, Pou4f2 and Isl1, are sufficient to specify the retinal ganglion cell fate. Proc Natl Acad Sci U S A. 2015 Mar 31;112(13):E1559-68
• All: 2 reference(s)