Gt(ROSA)26Sor^{tm6(CAG-Hoxc8,-EGFP)Mrc}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm6(CAG-Hoxc8,-EGFP)Mrc}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 6, Mario R Capecchi
• MGI ID: MGI:5749682
• Synonyms: CAGC8
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm6(CAG-Hoxc8,-EGFP)Mrc} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:227707
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Mutation details: The targeting construct introduced into the locus a CAG promoter driving bicistronic expression of mouse Hoxc8 cDNA and the EGFP reporter gene. Cre-mediated recombination is required to remove a floxed transcriptional stop sequence and neomyocin resistance cassette between the promoter and expressed sequences. (J:227707)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1089 strains or lines available

References

• Original: J:227707 Carroll LS, et al., Hoxc8 initiates an ectopic mammary program by regulating Fgf10 and Tbx3 expression and Wnt/beta-catenin signaling. Development. 2015 Dec 1;142(23):4056-67
• All: 1 reference(s)