Casp9^tm2.1Flv
Targeted Allele Detail

Summary

• Symbol: Casp9^tm2.1Flv
• Name: caspase 9; targeted mutation 2.1, Richard A Flavell
• MGI ID: MGI:5749648
• Synonyms: Caspase-9^flox
• Gene: Casp9 Location: Chr4:141520923-141543287 bp, + strand Genetic Position: Chr4, 74.75 cM, cytoband E1
• Alliance: Casp9^tm2.1Flv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:219206
• Parent Cell Line: JM8.F6 (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A floxed neo cassette was inserted upstream of exon 6 and a loxP site was inserted downstream of exon 6 via homologous recombination. Cre mediated recombination removed the neo cassette leaving exon 6 floxed. (J:219206)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Casp9 Mutation: 18 strains or lines available

References

• Original: J:219206 Rongvaux A, et al., Apoptotic caspases prevent the induction of type I interferons by mitochondrial DNA. Cell. 2014 Dec 18;159(7):1563-77
• All: 7 reference(s)