Cep120^tm1.1Blnw
Targeted Allele Detail

Summary

• Symbol: Cep120^tm1.1Blnw
• Name: centrosomal protein 120; targeted mutation 1.1, Baolin Wang
• MGI ID: MGI:5749512
• Synonyms: Cep120^f
• Gene: Cep120 Location: Chr18:53814795-53877680 bp, - strand Genetic Position: Chr18, 29.07 cM
• Alliance: Cep120^tm1.1Blnw page

Hydrocephalus, dilated brain ventricles, and smaller cerebellum in Cep120^tm1.1Blnw/Cep120^tm1.2BlnwTg(Nes-cre)1Atp/0 mice

Show the 5 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:220629
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

Allele Type: Targeted (Conditional ready) Mutation: Insertion Mutation details: An FRT flanked neo cassette and loxP site were inserted upstream of exon 4 and a loxP site was inserted downstream of exon 4 via homologous recombination. Flp mediated recombination removed the neo cassette leaving exon 4 floxed. (J:220629)

Generation of the Cep120^tm1.1Blnw and Cep120^tm1.2Blnw alleles

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cep120 Mutation: 49 strains or lines available

References

• Original: J:220629 Wu C, et al., Talpid3-binding centrosomal protein Cep120 is required for centriole duplication and proliferation of cerebellar granule neuron progenitors. PLoS One. 2014;9(9):e107943
• All: 3 reference(s)