Ncor1^tm1.1Mlpr
Targeted Allele Detail

Summary

• Symbol: Ncor1^tm1.1Mlpr
• Name: nuclear receptor co-repressor 1; targeted mutation 1.1, Martin L Privalsky
• MGI ID: MGI:5749373
• Synonyms: NCoRomega^-
• Gene: Ncor1 Location: Chr11:62207132-62348200 bp, - strand Genetic Position: Chr11, 38.08 cM, cytoband B2
• Alliance: Ncor1^tm1.1Mlpr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:224331
• Parent Cell Line: JM8.F6 (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting construct encompassing exons 34 to 41 introduced a GT to CC mutation that ablates the 5' donor site required for splicing of the omega isoform. Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette within intron 37. The delta isoform is not affected. (J:224331)

Expression

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ncor1 Mutation: 396 strains or lines available

References

• Original: J:224331 Goodson ML, et al., Alteration of NCoR corepressor splicing in mice causes increased body weight and hepatosteatosis without glucose intolerance. Mol Cell Biol. 2014 Nov 15;34(22):4104-14
• All: 2 reference(s)