Pikfyve^tm1.1Csab
Targeted Allele Detail

Summary

• Symbol: Pikfyve^tm1.1Csab
• Name: phosphoinositide kinase, FYVE type zinc finger containing; targeted mutation 1.1, Charles Abrams
• MGI ID: MGI:5749370
• Synonyms: PIKfyve^fl
• Gene: Pikfyve Location: Chr1:65225842-65317854 bp, + strand Genetic Position: Chr1, 32.94 cM, cytoband C3
• Alliance: Pikfyve^tm1.1Csab page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:224577
• Parent Cell Line: iTL IC1 (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Exons 37 and 38 were floxed. Flp-mediated recombination removed the neomycin resistance cassette. (J:224577)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pikfyve Mutation: 113 strains or lines available

References

• Original: J:224577 Min SH, et al., Loss of PIKfyve in platelets causes a lysosomal disease leading to inflammation and thrombosis in mice. Nat Commun. 2014;5:4691
• All: 3 reference(s)