Bcl6^tm1.1Mamu
Targeted Allele Detail

Summary

• Symbol: Bcl6^tm1.1Mamu
• Name: B cell leukemia/lymphoma 6; targeted mutation 1.1, Markus Muschen
• MGI ID: MGI:5749250
• Synonyms: Bcl6^fl
• Gene: Bcl6 Location: Chr16:23783802-23807602 bp, - strand Genetic Position: Chr16, 15.26 cM
• Alliance: Bcl6^tm1.1Mamu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:219919
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Reporter)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 5 and a loxP site and mCherry reporter gene were inserted downstream of exon 10 via homologous recombination. (J:219919)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bcl6 Mutation: 59 strains or lines available

References

• Original: J:219919 Geng H, et al., Self-Enforcing Feedback Activation between BCL6 and Pre-B Cell Receptor Signaling Defines a Distinct Subtype of Acute Lymphoblastic Leukemia. Cancer Cell. 2015 Mar 9;27(3):409-25
• All: 8 reference(s)