Zbtb46^{tm4.1(HBEGF)Mnz}
Targeted Allele Detail

Summary

• Symbol: Zbtb46^{tm4.1(HBEGF)Mnz}
• Name: zinc finger and BTB domain containing 46; targeted mutation 4, Michel C Nussenzweig
• MGI ID: MGI:5749237
• Synonyms: zDC^LSLDTR
• Gene: Zbtb46 Location: Chr2:181029555-181101219 bp, - strand Genetic Position: Chr2, 103.63 cM, cytoband H4
• Alliance: Zbtb46^{tm4.1(HBEGF)Mnz} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:230709
• Parent Cell Line: CY2.4 (ES Cell)
• Strain of Origin: B6(Cg)-Tyr^c-2J

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence)
• Mutation: Insertion
• Zbtb46^{tm4.1(HBEGF)Mnz} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HBEGF (1839)

  Hbegf

  (MGI:96070)

• Mutation details: An FRT-flanked neomycin resistance cassette and a loxP-Stop-loxP-IRES-DTR (human diptheria toxin receptor)-mCherry element were introduced to exon 5, immediately after the stop codon. The mCherry is not expressed effectively after excision of the excision of the Stop element and mice should not be used as reporter animals. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:230709)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Zbtb46 Mutation: 36 strains or lines available

References

• Original: J:230709 Loschko J, et al., Inducible targeting of cDCs and their subsets in vivo. J Immunol Methods. 2016 Jul;434:32-8
• All: 5 reference(s)