Grin2b^{tm1.1(Grin2a)Tmnb}
Targeted Allele Detail

Summary

• Symbol: Grin2b^{tm1.1(Grin2a)Tmnb}
• Name: glutamate receptor, ionotropic, NMDA2B (epsilon 2); targeted mutation 1.1, Toshiya Manabe
• MGI ID: MGI:5708642
• Synonyms: GluN2B-GluN2A
• Gene: Grin2b Location: Chr6:135690231-136150509 bp, - strand Genetic Position: Chr6, 66.38 cM
• Alliance: Grin2b^{tm1.1(Grin2a)Tmnb} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:228596
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Grin2b^{tm1.1(Grin2a)Tmnb} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Grin2a (MGI:95820)

• Mutation details: The cDNA encoding Grin2a knocked into the translation initiation site in exon 4. Cre-mediated recombination removed the floxed neomycin resistance cassette inserted downstream of cDNA. (J:228596)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Grin2b Mutation: 100 strains or lines available

References

• Original: J:228596 Hamada S, et al., The glutamate receptor GluN2 subunit regulates synaptic trafficking of AMPA receptors in the neonatal mouse brain. Eur J Neurosci. 2014 Oct;40(8):3136-46
• All: 1 reference(s)