Ehmt2^tm1Bzhu
Targeted Allele Detail

Summary

• Symbol: Ehmt2^tm1Bzhu
• Name: euchromatic histone lysine N-methyltransferase 2; targeted mutation 1, Bing Zhu
• MGI ID: MGI:5708540
• Synonyms: G9a 3A
• Gene: Ehmt2 Location: Chr17:35117445-35133028 bp, + strand Genetic Position: Chr17, 18.45 cM
• Alliance: Ehmt2^tm1Bzhu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:219788
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Three nucleotide substitutions were inserted in exon 19 (W791A/W796A/E799A) and a neo cassette was inserted in intron 21 via homologous recombination. This mutation disrupts methylated H3K9-binding activity. (J:219788)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ehmt2 Mutation: 55 strains or lines available

References

• Original: J:219788 Liu N, et al., Recognition of H3K9 methylation by GLP is required for efficient establishment of H3K9 methylation, rapid target gene repression, and mouse viability. Genes Dev. 2015 Feb 15;29(4):379-93
• All: 1 reference(s)