Gt(ROSA)26Sor^tm1Vgor
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^tm1Vgor
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Vera Gorbunova
• MGI ID: MGI:5708497
• Synonyms: R26NHEJ
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^tm1Vgor page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:228604
• Parent Cell Line: iTL IC1 (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Reporter)
• Mutation: Insertion
• Mutation details: The targeting construct introduced into the locus an NHEJ reporter cassette that consisted of GFP reporter gene exons separated by an I-SceI-flanked Pem1 intron, interrupted by the killer exon Ad2, and a floxed neomycin resistance cassette. (J:228604)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1089 strains or lines available

References

• Original: J:228604 Vaidya A, et al., Knock-in reporter mice demonstrate that DNA repair by non-homologous end joining declines with age. PLoS Genet. 2014 Jul;10(7):e1004511
• All: 2 reference(s)