Hdac11^tm1.2Mrl
Targeted Allele Detail

Summary

• Symbol: Hdac11^tm1.2Mrl
• Name: histone deacetylase 11; targeted mutation 1.2, Merck Research Laboratory
• MGI ID: MGI:5707970
• Synonyms: Hdac11^tm1Mrl
• Gene: Hdac11 Location: Chr6:91133652-91151674 bp, + strand Genetic Position: Chr6, 40.38 cM
• Alliance: Hdac11^tm1.2Mrl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:228570
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Not Specified
• The loxP flanked exon 3 was removed via Cre-mediated recombination generating a frame shift. (J:245003)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hdac11 Mutation: 19 strains or lines available

References

• Original: J:228570 Cheng F, et al., Divergent roles of histone deacetylase 6 (HDAC6) and histone deacetylase 11 (HDAC11) on the transcriptional regulation of IL10 in antigen presenting cells. Mol Immunol. 2014 Jul;60(1):44-53
• All: 14 reference(s)