Stk4^weet
Chemically induced Allele Detail

Summary

• Symbol: Stk4^weet
• Name: serine/threonine kinase 4; WeeT
• MGI ID: MGI:5707766
• Synonyms: Mst1^h, WeeT
• Gene: Stk4 Location: Chr2:163916033-163997444 bp, + strand Genetic Position: Chr2, 84.6 cM, cytoband H3
• Alliance: Stk4^weet page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Chemically induced (ENU) (Hypomorph)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced an A to C point mutation in exon 5 that results in the amino acid substitution of arginine for leucine at position 157 (L157R). Western blot analysis confirmed reduced protein expression in the presence or absence of proteosome (MG132) or caspase-3 inhibitor (Z-DEVD). (J:219121)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Stk4 Mutation: 72 strains or lines available

References

• Original: J:219121 Xu X, et al., Mst1 directs Myosin IIa partitioning of low and higher affinity integrins during T cell migration. PLoS One. 2014;9(8):e105561
• All: 1 reference(s)