Mdm4^tm1.1Tldo
Targeted Allele Detail

Summary

• Symbol: Mdm4^tm1.1Tldo
• Name: MDM4 regulator of p53; targeted mutation 1.1, Franck Toledo
• MGI ID: MGI:5707395
• Synonyms: Mdm4^deltaE6
• Gene: Mdm4 Location: Chr1:132913843-132958325 bp, - strand Genetic Position: Chr1, 57.75 cM, cytoband G-G
• Alliance: Mdm4^tm1.1Tldo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:222536
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 6 was replaced with a floxed neomycin resistance cassette. The deletion prevents expression of the full length isoform but allows for expression of the short isoform. Cre-mediated recombination removed the selection cassette. (J:222536)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mdm4 Mutation: 190 strains or lines available

References

• Original: J:222536 Bardot B, et al., Mice engineered for an obligatory Mdm4 exon skipping express higher levels of the Mdm4-S isoform but exhibit increased p53 activity. Oncogene. 2015 May 28;34(22):2943-8
• All: 1 reference(s)