Scn5a^tm1.1Pmoh
Targeted Allele Detail

Summary

• Symbol: Scn5a^tm1.1Pmoh
• Name: sodium channel, voltage-gated, type V, alpha; targeted mutation 1, Peter J Mohler
• MGI ID: MGI:5707220
• Synonyms: Scn5a^f
• Gene: Scn5a Location: Chr9:119312474-119408082 bp, - strand Genetic Position: Chr9, 71.33 cM
• Alliance: Scn5a^tm1.1Pmoh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:227075
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Exons 11 to 13 were flanked by loxP sites. (J:227075)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Scn5a Mutation: 103 strains or lines available

References

• Original: J:227075 Musa H, et al., SCN5A variant that blocks fibroblast growth factor homologous factor regulation causes human arrhythmia. Proc Natl Acad Sci U S A. 2015 Oct 6;112(40):12528-33
• All: 1 reference(s)