Ptgs2^tm3.1Hahe
Targeted Allele Detail

Summary

• Symbol: Ptgs2^tm3.1Hahe
• Name: prostaglandin-endoperoxide synthase 2; targeted mutation 3.1, Harvey R Herschman
• MGI ID: MGI:5706970
• Synonyms: Cox2^tm2Luc
• Gene: Ptgs2 Location: Chr1:149975851-149983978 bp, + strand Genetic Position: Chr1, 63.84 cM, cytoband H1
• Alliance: Ptgs2^tm3.1Hahe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:218934
• Parent Cell Line: LW1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A firefly luciferase gene and floxed neomycin resistance cassette replaced the coding sequence and left the endogenous 3' UTR intact. Cre-mediated recombination removed the selection cassette. (J:218934)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptgs2 Mutation: 68 strains or lines available

References

• Original: J:218934 Zaiss AK, et al., Reversible suppression of cyclooxygenase 2 (COX-2) expression in vivo by inducible RNA interference. PLoS One. 2014;9(7):e101263
• All: 1 reference(s)