Tigit^tm1Gne
Targeted Allele Detail

Summary

• Symbol: Tigit^tm1Gne
• Name: T cell immunoreceptor with Ig and ITIM domains; targeted mutation 1, Genentech
• MGI ID: MGI:5706759
• Synonyms: TIGIT^fl
• Gene: Tigit Location: Chr16:43469230-43484509 bp, - strand Genetic Position: Chr16, 28.44 cM
• Alliance: Tigit^tm1Gne page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:217453
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 1 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 1 via homologous recombination. (J:217453)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tigit Mutation: 15 strains or lines available

References

• Original: J:217453 Johnston RJ, et al., The immunoreceptor TIGIT regulates antitumor and antiviral CD8(+) T cell effector function. Cancer Cell. 2014 Dec 8;26(6):923-37
• All: 2 reference(s)