Pld2^tm1.1Kong
Targeted Allele Detail

Summary

• Symbol: Pld2^tm1.1Kong
• Name: phospholipase D2; targeted mutation 1.1, Young-Yun Kong
• MGI ID: MGI:5705825
• Gene: Pld2 Location: Chr11:70430890-70448936 bp, + strand Genetic Position: Chr11, 42.99 cM
• Alliance: Pld2^tm1.1Kong page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:227096
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A loxP sequence and neomycin cassette were inserted in intron 9 and a second loxP sequence in intron 6. Cre-mediated recombination removed exons 7 to 9. Western blotting analysis confirmed the absent of Pld2. (J:227096)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pld2 Mutation: 47 strains or lines available

References

• Original: J:227096 Ghim J, et al., Endothelial deletion of phospholipase D2 reduces hypoxic response and pathological angiogenesis. Arterioscler Thromb Vasc Biol. 2014 Aug;34(8):1697-703
• All: 4 reference(s)