Ms4a2^{tm1.1(tdTomato,-HBEGF)Mal}
Targeted Allele Detail

Summary

• Symbol: Ms4a2^{tm1.1(tdTomato,-HBEGF)Mal}
• Name: membrane-spanning 4-domains, subfamily A, member 2; targeted mutation 1.1, Bernard Malissen
• MGI ID: MGI:5705546
• Synonyms: Ms4a2^tm1Mal, RMB
• Gene: Ms4a2 Location: Chr19:11592887-11601083 bp, - strand Genetic Position: Chr19, 8.46 cM
• Alliance: Ms4a2^{tm1.1(tdTomato,-HBEGF)Mal} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:217638
• Parent Cell Line: JM8.F6 (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Ms4a2^{tm1.1(tdTomato,-HBEGF)Mal} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HBEGF (1839)

  Hbegf

  (MGI:96070)

• Mutation details: Sequence for the tdTomato reporter gene, 2A self-cleavage peptide sequence, the human diphtheria toxin receptor (HBEGF) cDNA, a loxP site, the mouse Ace (angiotensin I converting enzyme (peptidyl-dipeptidase A) 1) promoter, the cre recombinase gene, a neomycin resistance gene cassette, and a second loxP site, was inserted in the 3' UTR 14 bp downstream of the stop codon via homologous recombination. Cre-mediated recombination in the male germline removed the cre+neo cassette. (J:217638)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ms4a2 Mutation: 11 strains or lines available

References

• Original: J:217638 Dahdah A, et al., Mast cells aggravate sepsis by inhibiting peritoneal macrophage phagocytosis. J Clin Invest. 2014 Oct;124(10):4577-89
• All: 9 reference(s)