Unc93b1^letr
Chemically induced Allele Detail

Summary

• Symbol: Unc93b1^letr
• Name: unc-93 homolog B1, TLR signaling regulator; loss of endosomal TLR response
• MGI ID: MGI:5705541
• Gene: Unc93b1 Location: Chr19:3985222-3999340 bp, + strand Genetic Position: Chr19, 3.65 cM
• Alliance: Unc93b1^letr page

Mutation origin

• Strain of Origin: 129S1

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced an A to T point mutation in the 5' splice donor site in the intron between exons 4 and 5. The mutation disrupts splicing of exon 4 and excludes it from the transcript. (J:226653)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Unc93b1 Mutation: 39 strains or lines available

References

• Original: J:226653 Lafferty EI, et al., An ENU-induced splicing mutation reveals a role for Unc93b1 in early immune cell activation following influenza A H1N1 infection. Genes Immun. 2014 Jul-Aug;15(5):320-32
• All: 5 reference(s)