Cdkn2d^tm1.1Xhp
Targeted Allele Detail

Summary

• Symbol: Cdkn2d^tm1.1Xhp
• Name: cyclin dependent kinase inhibitor 2D; targeted mutation 1.1, Xin-Hai Pei
• MGI ID: MGI:5705146
• Synonyms: p19^-
• Gene: Cdkn2d Location: Chr9:21199759-21202553 bp, - strand Genetic Position: Chr9, 7.76 cM
• Alliance: Cdkn2d^tm1.1Xhp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:221632
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neomycin resistance cassette was inserted upstream of exon 1. An additional loxP was inserted downstream of exon2. Cre-mediated recombination removed the selection cassette and exons 1 and 2. Western blot analysis confirmed the absence of protein expression in mouse embryonic fibroblasts. (J:221632)

Tumor Data

List all tumor models in MMHCdb carrying Cdkn2d^tm1.1Xhp

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdkn2d Mutation: 22 strains or lines available

References

• Original: J:221632 Bai F, et al., p19Ink4d is a tumor suppressor and controls pituitary anterior lobe cell proliferation. Mol Cell Biol. 2014 Jun;34(12):2121-34
• All: 1 reference(s)