Rnf4^{Gt(RRR624)1.1Byg}
Gene trapped Allele Detail

Summary

• Symbol: Rnf4^{Gt(RRR624)1.1Byg}
• Name: ring finger protein 4; gene trap 1.1, BayGenomics
• MGI ID: MGI:5704318
• Synonyms: Rnf4^hypo
• Gene: Rnf4 Location: Chr5:34493594-34510789 bp, + strand Genetic Position: Chr5, 17.87 cM
• Alliance: Rnf4^{Gt(RRR624)1.1Byg} page

Mutation origin

• Mutant Cell Line: RRR624
• Germline Transmission: Earliest citation of germline transmission: J:227893
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Hypomorph, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT0Lxf Vector Type: gene trap
• Mutation details: The beta-geo gene trap inserted into intron 1. Cre-mediated recombination removed the splice acceptor. RT-PCR confirmed severely reduced transcript expression in E9.5 embryos. (J:227893)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rnf4 Mutation: 22 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

• Original: J:227893 Vyas R, et al., RNF4 is required for DNA double-strand break repair in vivo. Cell Death Differ. 2013 Mar;20(3):490-502
• All: 1 reference(s)