Myod1^tm2(Myf5)Mrc
Targeted Allele Detail

Summary

• Symbol: Myod1^tm2(Myf5)Mrc
• Name: myogenic differentiation 1; targeted mutation 2, Mario R Capecchi
• MGI ID: MGI:5704215
• Synonyms: MyoD^Myf5ki
• Gene: Myod1 Location: Chr7:46025898-46028516 bp, + strand Genetic Position: Chr7, 30.03 cM
• Alliance: Myod1^tm2(Myf5)Mrc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:217688
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Myod1^tm2(Myf5)Mrc expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Myf5 (MGI:97252)

• Mutation details: The Myf5 cDNA, FRT site, an IRES sequence, an EGFP reporter gene and an FRT site replaced 451 bp downstream of the translation initation site. (J:217688)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myod1 Mutation: 27 strains or lines available

Notes

This allele fails to rescue myogenesis in Myf5 deficient mice.

References

• Original: J:217688 Haldar M, et al., Response: Contributions of the Myf5-independent lineage to myogenesis. Dev Cell. 2014 Dec 8;31(5):539-41
• All: 1 reference(s)