Gt(ROSA)26Sor^{tm1(Ezh2)Sgon}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(Ezh2)Sgon}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Susana Gonzalez
• MGI ID: MGI:5703950
• Synonyms: cki-Ezh2^fl
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(Ezh2)Sgon} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:225016
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(Ezh2)Sgon} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Ezh2 (MGI:107940)

• Mutation details: The targeting construct introduced into the locus a loxP site, neomycin resistance cassette, STOP cassette, loxP site, Ezh2 cDNA, IRES sequence and EGFP reporter gene. Cre-mediated recombination is required to achieve expression of the inserted coding sequence. (J:225016)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1089 strains or lines available

References

• Original: J:225016 Herrera-Merchan A, et al., Ectopic expression of the histone methyltransferase Ezh2 in haematopoietic stem cells causes myeloproliferative disease. Nat Commun. 2012;3:623
• All: 1 reference(s)