Sdhb^tm1Dost
Targeted Allele Detail

Summary

• Symbol: Sdhb^tm1Dost
• Name: succinate dehydrogenase complex, subunit B, iron sulfur (Ip); targeted mutation 1, Douglas Strathdee
• MGI ID: MGI:5702640
• Synonyms: Sdhb^fl
• Gene: Sdhb Location: Chr4:140688582-140706509 bp, + strand Genetic Position: Chr4, 73.24 cM, cytoband E1
• Alliance: Sdhb^tm1Dost page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:227346
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A hygromycin resistance cassette with a 3' loxP site was inserted upstream of exon 3. An additional loxP site was inserted downstream of exon 3. (J:227346)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sdhb Mutation: 27 strains or lines available

References

• Original: J:227346 Cardaci S, et al., Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis. Nat Cell Biol. 2015 Oct;17(10):1317-26
• All: 3 reference(s)