Alk^tm1Dgen
Targeted Allele Detail

Summary

• Symbol: Alk^tm1Dgen
• Name: anaplastic lymphoma kinase; targeted mutation 1, Deltagen
• MGI ID: MGI:5700373
• Gene: Alk Location: Chr17:72175967-72911622 bp, - strand Genetic Position: Chr17, 43.77 cM
• Alliance: Alk^tm1Dgen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:226526
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Sequence from exon 22, containing 35bp coding for the protein, was replaced by a IRES-beta-gal-neomycin selection cassette. This mutation is predicted to lead to premature transcript termination and deletion of the transmembrane and kinase domains in the encoded protein. (J:226526)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Alk Mutation: 62 strains or lines available

References

• Original: J:226526 Bilsland JG, et al., Behavioral and neurochemical alterations in mice deficient in anaplastic lymphoma kinase suggest therapeutic potential for psychiatric indications. Neuropsychopharmacology. 2008 Feb;33(3):685-700
• All: 2 reference(s)