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Eosn2AKR/J
QTL Variant Detail
Summary
QTL variant: Eosn2AKR/J
Name: eosinophil differential 2; AKR/J
MGI ID: MGI:5697701
Synonyms: Eosn2AKR.129P2(B6)-Apoe-tm1Bres
QTL: Eosn2  Location: Chr13:17221311-17221311 bp  Genetic Position: Chr13, Syntenic
Variant
origin
Strain of Specimen:  AKR/J
Variant
description
Allele Type:    QTL
Inheritance:    Not Specified
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:106112

Linkage analysis was performed on 209 (AKR.129P2(B6)-Apoetm1Bres x D2.129P2(B6)-Apoetm1Bres)F2 intercross mice (95 female, 114 male) using 1967 markers to identify QTL associated with percent eosinophils as measured by complete bood count. The crosswas generated with the intent to identify QTL related to atherosclerosis. Parental strains AKR/J and DBA/2J are atherosclerosis resistant and sensitive, respectively.

QTL Eosn2 maps to Chromosome 13 with a peak LOD score of 4.49 at marker rs6307428 (17 Mb) in linkage with eosinophil percentage via CBC. AKR/J alleles confer increased susceptibility to percent eosinophils at the Eosn2 locus. Genetic mapping was performed relative to NCBI mouse genome build 34 and sex was used as an interactive covariate.

References
Original:  J:106112 Smith JD, et al., Atherosclerosis susceptibility loci identified from a strain intercross of apolipoprotein E-deficient mice via a high-density genome scan. Arterioscler Thromb Vasc Biol. 2006 Mar;26(3):597-603
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory