Mcal4^{B6.129P2-Apoe-tm1Unc/J}
QTL Variant Detail

Summary

• QTL variant: Mcal4^{B6.129P2-Apoe-tm1Unc/J}
• Name: medial calcification 4; B6.129P2-Apoe^tm1Unc/J
• MGI ID: MGI:5697505
• QTL: Mcal4 Location: unknown Genetic Position: Chr7, Syntenic

Variant origin

• Strain of Specimen: B6.129P2-Apoe^tm1Unc/J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Abcc6 is reported as a candidate gene for Mcal4.
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:182797

Linkage analysis was performed on 332 (B6.129P2-Apoe^tm1Unc/J x C3.129P2(B6)-Apoe^tm1Unc)F2 intercross mice using 1347 markers to identify QTL associated with aortic medial calcification. Parental strain C3H/HeJ displays higher susceptibility to aortic medial disruption than C57BL/6J.

QTL Mcal4 maps to 25.9 - 101.3 Mb on Chromosome 7 with a peak LOD score of 4.60 (sex-covariate) or 4.85 (sex-interaction) at 38.9 cM in linkage with aortic medial calcification. C57BL/6J alleles confer decreased susceptibility to aortic medial calcification at the Mcal4 locus. Abcc6 is reported as an Mcal4 candidate gene.

References

• Original: J:182797 Wang SS, et al., Disruption of the aortic elastic lamina and medial calcification share genetic determinants in mice. Circ Cardiovasc Genet. 2009 Dec;2(6):573-82
• All: 1 reference(s)