Summary |
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Variant origin |
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Variant description |
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Notes |
Mapping and Phenotype information for this QTL, its variants and associated markersJ:182797Linkage analysis was performed on 332 (B6.129P2-Apoetm1Unc/J x C3.129P2(B6)-Apoetm1Unc)F2 intercross mice using 1347 markers to identify QTL associated with aortic medial calcification. Parental strain C3H/HeJ displays higher susceptibility to aortic medial disruption than C57BL/6J. QTL Mcal1 maps to 34.5 - 133.7 Mb on Chromosome 6 with a peak LOD score of 5.81 (sex-covariate) or 5.58 (sex-interaction) at 125.7 cM in linkage with aortic medial calcification. Because of an inversion in the C3H/HeJ strain on chromosome 6, 125.7 cM may not accurately reflect the actual peak location of the Mcal1 QTL. C57BL/6J alleles confer decreased susceptibility to aortic medial calcification at the Mcal1 locus. |
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References |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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