Setxtm1.1Mfl
Targeted Allele Detail
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Symbol: |
Setxtm1.1Mfl |
Name: |
senataxin; targeted mutation 1.1, Martin F Lavin |
MGI ID: |
MGI:5697060 |
Gene: |
Setx Location: Chr2:29014193-29072483 bp, + strand Genetic Position: Chr2, 19.45 cM
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Alliance: |
Setxtm1.1Mfl page
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Small testis size and disrupted spermatogenesis in Setxtm1.1Mfl/Setxtm1.1Mfl mice
Show the 3 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:223053
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A floxed neomycin resistance cassette replaced exon 4. Cre-mediated recombination removed the selection cassette. Western blot analysis confirmed the absence of protein expression in testes.
(J:223053)
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Generation of the Setxtm1.1Mfl allele |
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Setx Mutation: |
141 strains or lines available
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Original: |
J:223053 Becherel OJ, et al., Senataxin plays an essential role with DNA damage response proteins in meiotic recombination and gene silencing. PLoS Genet. 2013 Apr;9(4):e1003435 |
All: |
6 reference(s) |
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