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Setxtm1.1Mfl
Targeted Allele Detail
Summary
Symbol: Setxtm1.1Mfl
Name: senataxin; targeted mutation 1.1, Martin F Lavin
MGI ID: MGI:5697060
Gene: Setx  Location: Chr2:29014193-29072483 bp, + strand  Genetic Position: Chr2, 19.45 cM
Alliance: Setxtm1.1Mfl page
Small testis size and disrupted spermatogenesis in Setxtm1.1Mfl/Setxtm1.1Mfl mice

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:223053
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA floxed neomycin resistance cassette replaced exon 4. Cre-mediated recombination removed the selection cassette. Western blot analysis confirmed the absence of protein expression in testes. (J:223053)
Generation of the Setxtm1.1Mfl allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 5 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Setx Mutation:  141 strains or lines available
References
Original:  J:223053 Becherel OJ, et al., Senataxin plays an essential role with DNA damage response proteins in meiotic recombination and gene silencing. PLoS Genet. 2013 Apr;9(4):e1003435
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory