Zfyve9^tm1.1Yty
Targeted Allele Detail

Summary

• Symbol: Zfyve9^tm1.1Yty
• Name: zinc finger, FYVE domain containing 9; targeted mutation 1.1, Yu-Ting Yan
• MGI ID: MGI:5696100
• Synonyms: SARA^delta
• Gene: Zfyve9 Location: Chr4:108494663-108637995 bp, - strand Genetic Position: Chr4, 50.64 cM
• Alliance: Zfyve9^tm1.1Yty page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:221071
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 2. Cre-mediated recombination removed exon 2 and the selection cassette. Western blot analysis confirmed the absence of protein isoforms 1 and 2 expression in mouse embyonic fibroblasts. (J:221071)

Expression

In Mice Carrying this Mutation:

4 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zfyve9 Mutation: 63 strains or lines available

References

• Original: J:221071 Chang HM, et al., The FYVE domain of Smad Anchor for Receptor Activation (SARA) is required to prevent skin carcinogenesis, but not in mouse development. PLoS One. 2014;9(8):e105299
• All: 1 reference(s)