Tnfaip3^tm1.1Gho
Targeted Allele Detail

Summary

• Symbol: Tnfaip3^tm1.1Gho
• Name: tumor necrosis factor, alpha-induced protein 3; targeted mutation 1.1, Sankar Ghosh
• MGI ID: MGI:5695623
• Synonyms: A20-C103A, A20-OTU
• Gene: Tnfaip3 Location: Chr10:18876658-18891158 bp, - strand Genetic Position: Chr10, 8.08 cM
• Alliance: Tnfaip3^tm1.1Gho page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:217021
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: B6(Cg)-Tyr^c-2J/J

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A cysteine to alanine mutation was inserted at position 103 (C103A) in exon 3 and a floxed neo cassette was inserted in intron 2 via homologous recombination. Cre mediated recombination removed the neo cassette. (J:217021)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tnfaip3 Mutation: 43 strains or lines available

Notes

ES cell line = CSL2J2

References

• Original: J:217021 De A, et al., The deubiquitinase activity of A20 is dispensable for NF-kappaB signaling. EMBO Rep. 2014 Jul;15(7):775-83
• All: 1 reference(s)