Cpt1b^tm1Myna
Targeted Allele Detail

Summary

• Symbol: Cpt1b^tm1Myna
• Name: carnitine palmitoyltransferase 1b, muscle; targeted mutation 1, Randall L Mynatt
• MGI ID: MGI:5695243
• Synonyms: Cpt1b^flox
• Gene: Cpt1b Location: Chr15:89300608-89310065 bp, - strand Genetic Position: Chr15, 44.89 cM
• Alliance: Cpt1b^tm1Myna page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:223761
• Parent Cell Line: PRX-B6-albino #1 (ES Cell)
• Strain of Origin: B6(Cg)-Tyr^c-2J/J

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The first loxP site was inserted into intron 10 followed by a loxP-flanked neo cassette in intron 15. Recombinase-mediated recombination removed the neo cassette, leaving exons 11-15 floxed. (J:223761)

Expression

In Mice Carrying this Mutation:

3 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cpt1b Mutation: 43 strains or lines available

References

• Original: J:223761 Wicks SE, et al., Impaired mitochondrial fat oxidation induces adaptive remodeling of muscle metabolism. Proc Natl Acad Sci U S A. 2015 Jun 23;112(25):E3300-9
• All: 6 reference(s)