Safb2^tm1So
Targeted Allele Detail

Summary

• Symbol: Safb2^tm1So
• Name: scaffold attachment factor B2; targeted mutation 1, Steffi Oesterreich
• MGI ID: MGI:5695073
• Gene: Safb2 Location: Chr17:56867965-56891585 bp, - strand Genetic Position: Chr17, 29.39 cM
• Alliance: Safb2^tm1So page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:225512
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 4-10 were replaced by an IRES-lacZ-SV40pA (beta-galactosidase) marker and a PGK-Neomycin-bGHpA selection cassette. Northern blot analysis indicated that no detectable transcript encoding the C-terminus is expressed from this allele. The N-terminus is expressed together with the introduced lacZ gene. LacZ is expressed in Sertoli cells. (J:225512)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Safb2 Mutation: 39 strains or lines available

References

• Original: J:225512 Jiang S, et al., Scaffold attachment factor B2 (SAFB2)-null mice reveal non-redundant functions of SAFB2 compared with its paralog, SAFB1. Dis Model Mech. 2015 Sep 1;8(9):1121-7
• All: 1 reference(s)