Npw^{tm1.1(icre)Ymf}
Targeted Allele Detail

Summary

• Symbol: Npw^{tm1.1(icre)Ymf}
• Name: neuropeptide W; targeted mutation 1.1, Masa Fu Yanagisawa
• MGI ID: MGI:5694675
• Synonyms: NPW-iCre
• Gene: Npw Location: Chr17:24876304-24877431 bp, - strand Genetic Position: Chr17, 12.45 cM
• Alliance: Npw^{tm1.1(icre)Ymf} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:225431
• Parent Cell Line: RENKA (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Npw^{tm1.1(icre)Ymf} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Npw (MGI:2685781)

• Mutation details: An improved cre recombinase gene and FRT-flanked neomycin resistance cassette were inserted at the translation initiation sequence in exon 1. Flp-mediated recombination removed the selection cassette. (J:225431)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Npw (mouse) Summary of all recombinase alleles driven by Npw. Comparative matrix view of recombinase activities Alliance mouse Npw gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Npw Mutation: 9 strains or lines available

References

• Original: J:225431 Motoike T, et al., Transient expression of neuropeptide W in postnatal mouse hypothalamus--a putative regulator of energy homeostasis. Neuroscience. 2015 Aug 20;301:323-37
• All: 1 reference(s)