Sxbq4^C57BL/6Slc
QTL Variant Detail

Summary

• QTL variant: Sxbq4^C57BL/6Slc
• Name: SGC/Knj cross B6 QTL 4; C57BL/6Slc
• MGI ID: MGI:5694115
• QTL: Sxbq4 Location: unknown Genetic Position: Chr10, cM position of peak correlated region/allele: 16.53 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: C57BL/6Slc

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:108420

Linkage analysis was performed on 420 female animals from a (C57BL/6Slc x SCG/Knj)F2 intercross to identify QTL for renal phenotypes. Parental strain SCG/Knj is derived from BXSB/Mp and MRL/Mp-Fas^lpr, and spontaneously develops crescentic glomerulonephritis and vascularitis. The Fas-^lpr mutation is largely responsible for the disease phenotype but this experiment seeks to identify non-Fas disease-associated loci. 102 polymorphic markers covering 85% of the genome at a 20 cM resolution was used for the genome scan. F2 animals were analyzed by cohorts grouped according to genotype at the Fas locus.

On mouse Chromosome 10, significant linkage to anti-ssDNA antibodies at 12 and 24 weeks of age (LOD=3.87-4.5; 9%-10% of variance) and MPO-ANCA production at 24 weeks of age (LOD=3.6; 9% of variance) mapped to 20 cM near D10Mit3. This locus is named Sxbq4(SGC/Knj cross B6 QTL 4). A separate symbol, Mancq2, is used to represent linkage to MPO-ANCA. Heterozygosity at Sxbq4/Mancq2 confers increased antibody traits and appears to require homozygosity for the Fas^lpr mutation to exert an effect. Previously identified autoimmune QTL Lmb4 (41 cM) and Asm1 (39 cM) map near this locus. Ifngr1 (15 cM) and Myb (16 cM) are potential candidate genes for Sxbq4.

References

• Original: J:108420 Hamano Y, et al., Genetic dissection of vasculitis, myeloperoxidase-specific antineutrophil cytoplasmic autoantibody production, and related traits in spontaneous crescentic glomerulonephritis-forming/Kinjoh mice. J Immunol. 2006 Mar 15;176(6):3662-73
• All: 1 reference(s)