Alpq6^HAP1
QTL Variant Detail

Summary

• QTL variant: Alpq6^HAP1
• Name: alcohol preference QTL 6; HAP1
• MGI ID: MGI:5693418
• QTL: Alpq6 Location: Chr3:137772078-137772078 bp Genetic Position: Chr3, Syntenic

Variant origin

• Strain of Specimen: HAP1

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:153380

High alcohol preferring mice (HAP) and low alcohol preferring mice (LAP) were utilized in a genome wide scan using SNPs to identify QTL that influence alcohol preference. A total of 989 (HAP1 x LAP1) F2 mice were tested.

Significant QTL were found in mouse Chromosomes 1 (2 loci), 3, 5 and 9.

The chromosome 9 mapping reaffirmed the location mapped as Alpq1 by Bice in 2006. J:110926 Behav Genet 2006 Mar;36(2):248-60. Epub 2006 Feb 15.

Alpq4 mapped in chromosome 1 with rs13475706 at 1.0 cM and Alpq5 also mapped in chromosome 1 with rs13476012 at 56 cM.

The chromosome 3 QTL Alpq6 mapped with rs13477439 at 74 cM. The chromosome 5 QTL Alpq7 mapped with rs8239888 at 83 cM.

A second locus in chromosome 9 and identified by MGI as Alpq8 mapped with rs13480399 at 75 cM, this locus was more distal then the locus mapped by Bice in 2006.

References

• Original: J:153380 Bice P, et al., Genomewide SNP screen to detect quantitative trait loci for alcohol preference in the high alcohol preferring and low alcohol preferring mice. Alcohol Clin Exp Res. 2009 Mar;33(3):531-7
• All: 1 reference(s)