Tpcn2^{tm1c(EUCOMM)Hmgu}
Targeted Allele Detail

Summary

• Symbol: Tpcn2^{tm1c(EUCOMM)Hmgu}
• Name: two pore segment channel 2; targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
• MGI ID: MGI:5692810
• Synonyms: Tpcn2^fl
• Gene: Tpcn2 Location: Chr7:144740261-144837748 bp, - strand Genetic Position: Chr7, 89.02 cM
• Alliance: Tpcn2^{tm1c(EUCOMM)Hmgu} page
• IMPC: Tpcn2 gene page

Mutation origin

• Mutant Cell Line: HEPD0665_2_C10
• Germline Transmission: Earliest citation of germline transmission: J:204739
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion Vector: L1L2_Bact_P
• Mutation details: Flp-mediated excision of the parental Tpcn2^{tm1a(EUCOMM)Hmgu} allele resulted in the removal of the promoter-driven neomycin selection cassette and the inserted lacZ reporter sequence, leaving behind exon 6 flanked by loxP sites. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:204739)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Tpcn2 Mutation: 53 strains or lines available

References

• Original: J:204739 International Knockout Mouse Consortium, MGI download of modified allele data from IKMC and creation of new knockout alleles. Database Download. 2014-2023
• All: 2 reference(s)