Fl1n^C3H/He
QTL Variant Detail

Summary

• QTL variant: Fl1n^C3H/He
• Name: fatty liver 1 in NSY; C3H/He
• MGI ID: MGI:5692016
• QTL: Fl1n Location: Chr6:45290993-128811995 bp Genetic Position: Chr6, Syntenic

Variant origin

• Strain of Specimen: C3H/He

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:130050

Nagoya-Shibata-Yasuda (NSY) mice, an animal model for diabetes, were mated with C3H/He

For QTL mapping 302 F2 informative mice were produced by crossing male NSY mice with female C3H/He mice.

The phenotypes assessed were body weight, blood glucose levels, and the livers were inspected to assess the degree of fatty liver. For QTL mapping a total of 109 microsatellite markers were used to cover the

whole mouse genome . QTL analysis was performed using Map Manager QTXb20.

LOD values for significant or suggestive linkage were presented.

Bw1n a QTL for body weight mapped to mouse Chromosome 7 between D7Mit81 and D7Mit238 with a peak LOD of approximately 5.1 at D7Mit61. The peak was broad. Suggestive linkage to body weight was also found in mouse Chromosomes 10 and 15.

Fl1n a QTL for fatty liver was found in mouse Chromosome 6 between D6Mit223 and D6Mit135, a peak for Flln with an associated LOD of 10 was found at D6Mit54.

Genomic evidence was presented suggesting Pparg as a candidate gene underlying the Flln phenothpe.

References

• Original: J:130050 Itoi-Babaya M, et al., Fatty liver and obesity: phenotypically correlated but genetically distinct traits in a mouse model of type 2 diabetes. Diabetologia. 2007 Aug;50(8):1641-8
• All: 1 reference(s)