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Bmc8C57BL/6J
QTL Variant Detail
Summary
QTL variant: Bmc8C57BL/6J
Name: bone mineral content 8; C57BL/6J
MGI ID: MGI:5690010
QTL: Bmc8  Location: unknown  Genetic Position: Chr7, Syntenic
Variant
origin
Strain of Specimen:  C57BL/6J
Variant
description
Allele Type:    QTL
Inheritance:    Not Specified
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:117547

Genetic loci associated with body composition were mapped using 369 animals from a (C57BL/6J x CASA/Rk)F2 intercross. A panel of 255 polymorphic markers at an average spacing of 5.9 cM was used for genome scan. Parental strain C57BL/6J displays decreasedactivity and increased weight, lean tissue mass, abdominal fat mass, body length, bone mineral density (BMD), bone area, and bone mineral content (BMC) compared to parental strain CASA/Rk. Males from C57BL/6J display increased body mass index (BMI) and total body fat tissue mass (FTM) compared to males from CASA/Rk.

Linkage to bone area mapped to 53 cM on mouse Chromosome 7 and is named Ba1 (LOD=4.71). Linkage to bone area in males is named Ba4 and also mapped to 53 cM with LOD=4.12. Linkage to bone mineral content to 15 cM (Bmc3, LOD=4.42), and mapped to 53 cM (Bmc8, LOD=3.45) in males.

References
Original:  J:117547 Vitarius JA, et al., Identification of quantitative trait loci affecting body composition in a mouse intercross. Proc Natl Acad Sci U S A. 2006 Dec 26;103(52):19860-5
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory