Cath2^{B6.129P2-Apoe-tm1Unc/J}
QTL Variant Detail

Summary

• QTL variant: Cath2^{B6.129P2-Apoe-tm1Unc/J}
• Name: carotid atherosclerosis 2; B6.129P2-Apoe^tm1Unc/J
• MGI ID: MGI:5689917
• QTL: Cath2 Location: unknown Genetic Position: Chr5, Syntenic

Variant origin

• Strain of Specimen: B6.129P2-Apoe^tm1Unc/J

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:197549

Linkage analysis was performed on 266 female (B6.129P2-Apoe^tm1Unc/J x C.129P2(B6)-Apoe^tm1Unc)F2 intercross mice using 130 SNP markers to identify QTL associated with susceptibility to athleroscotic carotid lesion. QTL mapping was performed using a nonparametric method.

QTL Cath2 maps to 48.46 - 66.68 cM on Chromosome 5 with a peak LOD score of 6.615 at 56.68 cM in linkage with athleroscotic carotid lesion incidence. B6.129P2-Apoe^tm1Unc/J alleles confer increased susceptibility to athleroscotic carotid lesion with a dominant mode of inheritance.

References

• Original: J:197549 Rowlan JS, et al., New quantitative trait loci for carotid atherosclerosis identified in an intercross derived from apolipoprotein E-deficient mouse strains. Physiol Genomics. 2013 Apr 16;45(8):332-42
• All: 1 reference(s)