Grm1^m1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Grm1^m1Btlr
• Name: glutamate receptor, metabotropic 1; mutation 1, Bruce Beutler
• MGI ID: MGI:5688490
• Synonyms: donald
• Gene: Grm1 Location: Chr10:10561803-10958100 bp, - strand Genetic Position: Chr10, 3.44 cM, cytoband A2
• Alliance: Grm1^m1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a a C to A transversion at base pair 10,741,508 (v38) on chromosome 10, or base pair 340,870 in the GenBank genomic region NC_000076. The mutation corresponds to residue 1,931 in the NM_016976 mRNA sequence in exon 6 of 9 total exons and residue 1,931 in the NM_001114333 mRNA sequence in exon 6 of 10 total exons. The mutation results in substitution of tyrosine 510 (Y510) for a premature stop codon (Y510*) in all isoforms. (J:224657)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Grm1 Mutation: 78 strains or lines available

References

• Original: J:224657 Reyna C, et al., Mutagenetix entry for donald. MGI Direct Data Submission. 2015
• All: 1 reference(s)