Mtdh^tm1.1Dsar
Targeted Allele Detail

Summary

• Symbol: Mtdh^tm1.1Dsar
• Name: metadherin; targeted mutation 1.1, Devanand Sarkar
• MGI ID: MGI:5662532
• Synonyms: AEG-1 CKO
• Gene: Mtdh Location: Chr15:34082613-34143683 bp, + strand Genetic Position: Chr15, 13.98 cM, cytoband B3.3
• Alliance: Mtdh^tm1.1Dsar page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:216688
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 1 and a floxed pgk-neo cassette was inserted downstream of exon 1 via homologous recombination. Cre mediated recombination removed the neo cassette. (J:216688)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mtdh Mutation: 32 strains or lines available

References

• Original: J:216688 Robertson CL, et al., Genetic deletion of AEG-1 prevents hepatocarcinogenesis. Cancer Res. 2014 Nov 1;74(21):6184-93
• All: 2 reference(s)