Ddr2tm1.1(cre/Esr1*)Rcow
Targeted Allele Detail
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Symbol: |
Ddr2tm1.1(cre/Esr1*)Rcow |
Name: |
discoidin domain receptor family, member 2; targeted mutation 1.1, Randy T Cowling |
MGI ID: |
MGI:5662369 |
Synonyms: |
Ddr2null |
Gene: |
Ddr2 Location: Chr1:169799876-169938331 bp, - strand Genetic Position: Chr1, 76.84 cM, cytoband H1-H5
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Alliance: |
Ddr2tm1.1(cre/Esr1*)Rcow page
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Allele Type: |
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Targeted (Inducible, Null/knockout, Recombinase) |
Inducer: |
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tamoxifen |
Mutations: |
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Insertion, Intragenic deletion
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Ddr2tm1.1(cre/Esr1*)Rcow expression driven by
1 gene
Knock-in expression driven by:
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Mutation details: Part of exon 3 was replaced with two mutated mouse estrogen receptors that sequester cre to the cytoplasm, polyadenylation sequence and an FRT-flanked neomycin resistance cassette. Flp-mediated recombination removed the selection cassette. Western blot analysis confirmed the absence of protein expression in cultured cardiac fibroblasts. Only low expression of the modified cre product was detected.
(J:214642)
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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Ddr2
(mouse)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Ddr2 Mutation: |
60 strains or lines available
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Original: |
J:214642 Cowling RT, et al., Discoidin domain receptor 2 germline gene deletion leads to altered heart structure and function in the mouse. Am J Physiol Heart Circ Physiol. 2014 Sep 1;307(5):H773-81 |
All: |
3 reference(s) |
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