Chrna7^tm1.1Swr
Targeted Allele Detail

Summary

• Symbol: Chrna7^tm1.1Swr
• Name: cholinergic receptor, nicotinic, alpha polypeptide 7; targeted mutation 1.1, Scott W Rogers
• MGI ID: MGI:5662226
• Synonyms: Chrna7-IRES-tauGFP, Chrna7-IRES-tGFP
• Gene: Chrna7 Location: Chr7:62748440-62862274 bp, - strand Genetic Position: Chr7, 34.47 cM
• Alliance: Chrna7^tm1.1Swr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:223063
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The stop codon was replaced with a hemagglutinin (HA) epitope tag (YPYDVPDY), IRES, tauGFP and an FRT-flanked neomycin resistance cassette. Flp-mediated recombination removed the selection cassette. (J:223063)

Expression

In Mice Carrying this Mutation:

47 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Chrna7 Mutation: 49 strains or lines available

References

• Original: J:223063 Rogers SW, et al., Prenatal ablation of nicotinic receptor alpha7 cell lineages produces lumbosacral spina bifida the severity of which is modified by choline and nicotine exposure. Am J Med Genet A. 2012 May;158A(5):1135-44
• All: 7 reference(s)