About   Help   FAQ
Berr5C57BL/6
QTL Variant Detail
Summary
QTL variant: Berr5C57BL/6
Name: berghei resistance locus 5; C57BL/6
MGI ID: MGI:5661591
QTL: Berr5  Location: unknown  Genetic Position: Chr19, Syntenic
Variant
origin
Strain of Specimen:  C57BL/6
Variant
description
Allele Type:    QTL
Inheritance:    Not Specified
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:163229

Linkage analysis was performed on 257 (C57BL/6 BALB/c)F2 intercross mice using 252 markers to identify QTL associated with susceptibility to Cerebral malaria (survival time).

QTL Berr5 maps to 29.3 - 41.3 Mb on Chromosome 19 with a peak LOD score of 4.69 at 32.3 Mb in linkage with Cerebral malaria susceptibility. C57BL/6 alleles convey susceptiblity to Cerebral malaria, with the majority of animals dying during the early cerebral phase of infection. Conversely, BALB/c mice were resistant to PbA-induced CM, with >75-80% of the animals surviving the cerebral phase. BALB/c alleles convey increased survival through the cerebral phase of infection but have no quantitative effect on parasitemia during the later, anemic phase.

References
Original:  J:163229 Berghout J, et al., Identification of a novel cerebral malaria susceptibility locus (Berr5) on mouse chromosome 19. Genes Immun. 2010 Jun;11(4):310-8
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory