Maf1^em1Lnh
Endonuclease-mediated Allele Detail

Summary

• Symbol: Maf1^em1Lnh
• Name: MAF1 homolog, negative regulator of RNA polymerase III; endonuclease-mediated mutation 1, Nouria Hernandez
• MGI ID: MGI:5661490
• Synonyms: Maf1 +T
• Gene: Maf1 Location: Chr15:76235494-76238578 bp, + strand Genetic Position: Chr15, 35.75 cM, cytoband E1
• Alliance: Maf1^em1Lnh page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Insertion
• Mutation details: Zinc finger nuclease (ZFN) editing induced a single base pair mutation in the Maf1 gene. The resulting change in reading frame causes a termination of translation after Thr64. (J:222253)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Maf1 Mutation: 11 strains or lines available

References

• Original: J:222253 Bonhoure N, et al., Loss of the RNA polymerase III repressor MAF1 confers obesity resistance. Genes Dev. 2015 May 1;29(9):934-47
• All: 2 reference(s)