Hbb-b2^tm1.1Bulg
Targeted Allele Detail

Summary

• Symbol: Hbb-b2^tm1.1Bulg
• Name: hemoglobin, beta adult minor chain; targeted mutation 1.1, Michael Bulger
• MGI ID: MGI:5660892
• Synonyms: deltaBeta2Pr
• Gene: Hbb-b2 Location: unknown Genetic Position: Chr7, 54.85 cM
• Alliance: Hbb-b2^tm1.1Bulg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:216256
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neo cassette replaced 600 bp of the promoter region, up to the first 25 bp of exon 1 (+43653-44287), via homologous recombination. Cre mediated recombination removed the neo cassette. Quantitative RT-PCR confirmed the absence of expression in peripheral blood and fetal liver from homozygous mice. (J:216256)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hbb-b2 Mutation: 5 strains or lines available

References

• Original: J:216256 Cadiz-Rivera B, et al., The chromatin "landscape" of a murine adult beta-globin gene is unaffected by deletion of either the gene promoter or a downstream enhancer. PLoS One. 2014;9(5):e92947
• All: 1 reference(s)